I use 3 Sony CDP-XP 450 changers controlled by an Escient Tunebase 100 (
http://www.escientconvergence.com/tb100.htm) and switched by the Nirvis DXS switch (
http://www.nirvis.com/dxs.htm).
The DXS switch is pretty neat for switching digital sources. All the changers are digitally connected to it and the most recent source routed to its outputs, so it gets over the analogue pass through problem. It is also powerful enough to drive long lengths of coax, the jukebox is in my loft, about a 25m run away from the Meridian kit.
I'm really happy with it. The sound quality is great (probably because the Meridian kit is excellent at cleaning up the signal). The Escient unit really makes navigation of an entire collection simple.
I chose this solution over Hard Disk based units as I didn't want compressed audio plus I figured that given it takes 20 mins to rip a CD, working 8 hrs a day at weekends and 2 hours a night during the week it would take me nearly 4 months to rip my collection of 1200 cds. The advice from my dealer on this point was to hire a student to do it!
You could still add a CD writer to the set up if you needed to make occaisional copies for the car etc.