1) Best ask Meridian support direct.
2) I don't think so. I just tried it in MConfig. If you specify stereo subs, the front DSPs are set to small. If you specify front/back subs, you don't get the bass-heavy option. If you specify a mono sub and daisy chain, you lose the bass-heavy option if the center is set to large...
3) Not exactly. You can configure "phantom" video sources which leave the audio input as "Last valid", but you might have difficulty not changing other settings such as the current DSP preset.
4) Yes. You have to install serial USB drivers in your PC.
5) Your options are limited. During MConfig setup you can state whether any DSP speaker is 96/24 cabable. If it is, bit depth is 24-bits. If not, I believe it is 18-bits, but please confirm with Meridian. If you specify 96/24 capable DSPs, then you get a "high sample" rate (HS) option which can be toggled any time you like. HS off gives you 44.1kHz from CD and 48kHz from decoded bitstreams. HS on gives you 2x upsampling.