This question should probably be its own thread, but you can do it in one of two ways...
1. Latest version of REW supports multichannel sweeps. Check settings/preferences doesn't have stereo only ticked. Then you can choose your channel, assuming your PC is directly connected via HDMI to an HDMI input on your HD621.
2. If you are using any other input, you can "force" centre sweeps by using prologic modes, but you will be limited to whatever the bass management speaker sizes are set to. Similarly for sub measurements you can turn off other speakers and do a sweep on L+R with just the sub on to measure that.