I use Roon directly connected to HD621/UHD722 via HDMI out from ROCK, and it works with multichannel if you tell HD621/UHD722 to handle 6 or 8 channels.

TV room: 861v8, 800v4, UHD722,Front 2xDSP7200SE, DSP7200HCSE, Side DSP5200, Rear DSP33, DSW, (DD 15 Sub),
Roon Rock NUC, QNAP NAS, Chromecast Ultra, Apple TV, Oppo BDP-105D, Pro-ject Pre box S2 digital, Philips Pronto remotes, Supra LoRad Power.
Office: 800v3, MS200, DSP3100
Basement: MS600, 502, 557, Dynaudio 52se, Dynaudio Sub 250