Are Intel NUCs especially noisy? Compared to any ethernet ports on a Cisco switch, iSilencer seems to audibly help when plugged into my Roon ROCK server.

No way does it come anywhere close a Network Acoustics filter.

Server: Audiolinux Roon NUC w/HAF room correction and crosstalk cancellation
Theater: 218, Allo Signature, miniDSP, HD621, C61R, DSP5200SEu, 420, 33, NHT subs
EtherREGEN w/Finisar fiber, Shunyata Denali
Living Room: RPi4 Diretta Host & Target, Ghent USB > Singxer SU-6 > AES NA M-Links > DSP9
Shunyata TritonV3, LHY lps, Farad Super3, Stack AUVA feet