I don't know whether this actually answers your question but I have Roon running as core on a QNAP 'Silent NAS' with no problems. I also have my library stored on it as well.
Just need to make sure that you have sufficient RAM in the QNAP to run the core ideally min. 4GB.

Rod

818v3, QNAP HS-453DX, Roon, 7200SE, ARCAM AVR380, REL B2, Panasonic BD 80, LG OLED, SBox Transporter, iPad, F80. Shunyata Delta NR power cables.