Not at present. I did have one handshake problem with one source (Panasonic sat receiver connected via 5m cable) which was solved by adding a HDMI booster. My current Humax receiver is fine.

Edit:
I do have to force players to deliver 3D Bluray as my projector's EDID (I can play 3D) seems to get lost going through both the HD621 and XS.

Main system - Sources (Kodi-HTPC, Vero 4k, FireTV, Sat) into Trinnov Altitude 32 (8-16) (+Roon), Trinnov Amplitude 8 amp & Vivid Audio (Giya G3, V1.5) and REL Stentor III speakers. Others: F80 + Raspberry Pi and other Pi systems.