That's my setup. Plex server on a Mac Mini controlled by a Harmony remote which will fire everything up (the Mac is left on all the time to serve iPads etc), the Harmony will control Plex, or I can use an iPad to control display on the main tv instead. All files are on a NAS and are mainly Apple friendly M4V and MKV which avoids any issues with transcoding so no need for any extra NAS processing power

Geoff

861v4-LPS, ID40, MC200, Roon, Tidal
DSP7000, DSP5200HC, DSP5000.3, Oracle Delphi IV, SME V, Dynavector DV17mk3.
Mac Mini(2010), Synology NAS/Plex Server
Schitt Lyr, Audeze LCD-2, Sennheiser HD800, Beyer Terminator v4.
Oppo BDP-93/Vanity93Lite, Sony PW-10, Grandview 100" screen