I have Apple TV 3's and two Dune's for video streaming. The ATV's in US have a 1080p video rental selection for TV shows and movies that is pretty good, for lossless video/audio viewing in the HT I use MKV's and Zappiti for my jukebox.
Z has a good iPad app for browsing movies/TV shows (they may have also released an Android app recently).
Lossless Bluray rips are very disk space intensive. I have learned a lot about ZFS and NAS technologies while struggling to scale to the space needed to store my fav films in BD 1080p.
IMHO you have to consider a Zappiti/Plex/iTunes library mgmt solution in addition to your hardware criteria.
Don't forget about backing up all you've ripped and storing offsite.
I want to manage without so many boxes if I can, but assume you're supporting lots of TVs and I only have 1. I agree that a library management solution is a bonus and the metadata offered by Plex would be an improvement on the list of .iso files that I have at present.
Re backup, I don't have offsite, but do have an external drive hooked up to my NAS for backups.