I'm not using Meridian DSP speakers so I don't have the luxury of tilt setting but I do have L/C/R actives which use the same drive units and amps to produce accurate timbre matching. This is important for Trifield as noted above.
I have a horizontal centre for the same reason as most people - screen height - and thus my center tweeter is about 12 inches lower than the tweeters on the L/R pair. I am pleased to say that despite this the integration of the system is very good with clear imaging on music sources. The effect of mis-alignment is very difficult to judge on films anyway.
I put this good performance down to wide and even dispersion of the mid and treble rather than the beaming effect from some systems. You retain good image specificity over a wider listening area.
Malcolm