Matching cartridge output, gain in the phono stage to try and hit the input specification of the 221 is not going to be very easy? A highish output moving magnet cartridge such as the Rega/Goldring ones (6.5-7.5mV) average step up of several quality phono stages I've just looked up such as Rega ProJect and Graham Slee 100-120x would give you an output from your phono-stage of about 1V on a good day. If you need 2.2V to get full bit depth from the 221 it looks like you are likely to need another gain stage somewhere?

Main system; 861v8 ID41, DSP8000SEU fronts with DSP5500 centre and DSP7000 rears (all in lovely silver) 504, HD621
Second system 861v4 ID40 LPS, G98DH, 504, HD621, 2x DSP5200 with DSP5200 centre
MD600 tucked away in study. Lots of other Meridian!