Joel,
Not weighing in as an expert but as a member that settled on an equalized, non-acoustically perfect room, I question how you would achieve what you want with all DSP speakers.
In terms of calibration and integration of the subs this is why I went with Tony Grimani because he lives and breathes this stuff and, with the proper EQ equipment, the system would sing (pun inetended)!
You could eq the subs but your room would need more than Meridian's basic EQ ability to sing. This is the current hitch with an all M speaker system for me. I use the NeptuneEQ with conventional speakers to great effect. I would love an all DSP system if I could integrate my EQ into the equation. IMO, to go all digital would require a pretty good room to start with if you expect it to truly shine.
Dave