The speaker doesn't know: it's all in the configuration settings in the 565. You're going to have to get to know them sooner or later, so start now!
The pages you should read are called 'Speaker Layouts' and I would guess that Layout A would be a good starting point. (Meridian can't decide if 5000s are 'small' or 'large' speakers.)
With layout A you will need that funny little 'SY lead' that comes in the box with the subwoofer. See Figure 1, page 6, for a wiring diagram that is probably pretty close to what you're aiming for.
- Pete