When I had by speakers on large I had them on a fairly low size setting as this was the point where I thought they were beginning to distort in the test. (There's a fine line between protecting your speakers and damaging them in the test itself!).
I'm with Ron on this, set them to max and go easy with volume. I would always set them to small for cinema modes though, as it's quite wasy to get carried away after a few beers
I run my speakers as small for all modes now with a fairly low X-over of 40Hz for music. The only time they run as full range is in Direct mode.
Cliff