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Even the room acoustics can fog the differences in detail and soundstage depth/height/width/macro & micro dynamics/timing that makes the differences noticable
To me, this is part of the point in reverse. Things like room treatment can make a huge difference that you don't have to listen for -- that is where the focus should be before cables. Otherwise is cart before the horse.

I've heard subtle differences among properly designed cables, but I think this is the manufacturer voicing them. I've come around to wanting cables that do nothing so they're not in the equation, and then I'll work w/things like room treatment, speaker choice, etc. I buy pro cables now; canare/belden, stuff like blue jeans cables sells. Such cable is designed for recording studios where thousands of feet of cable, power cords and so on are run so you can be sure that shielding will be good and they'll be neutral as demanded.